নির্দেশনা
Lymecycline is indicated for the treatment of acne, ear, nose and throat infections, acute exacerbation of chronic bronchitis, gastro-intestinal infection, urinary tract infection, non-gonococcal urethritis, trachoma, rickettsial fever, soft tissue infection.
Composition
ফার্মাকোলজি
Lymecycline is is approximately 5000 times more soluble than tetracycline base and is unique amongst tetracyclines in that it is absorbed by an active transport process across the intestinal wall, ensuring greater absorption. Lymecycline is a tetracycline derivative which blocks the access of bacterial aminoacyl-tRNA to the mRNA-ribosome complex by binding to the 30S ribosome subunit, preventing the addition of amino acids to the growing peptide chain in protein synthesis
মাত্রা ও সেবনবিধি
Adults : The usual dosage for the chronic treatment of acne is 1 capsule daily: Treatment should be continued for at least 8 weeks. For other infections, the usual dosage is 1 capsule twice daily. If higher doses are required, 3-4 capsules may be given over 24 hours. Duration should be determined by the physician. Lower doses may be given for prophylaxis. Elderly : As for other tetracyclines, no specific dose adjustment is required. Children : Not recommended for children under the age of 12 years. For children over the age of 12 years the adult dosage may be given. Lymecycline capsule should always be taken with a glass of water.
প্রতিনির্দেশনা
Hypersensitivity to lymecycline or other tetracyclines. Overt renal insufficiency. Pregnancy and lactation. Concomitant use with methoxuflurane or oral retinoids.
পার্শ্ব প্রতিক্রিয়া
Care should be exercised in administering Lymecycline to patients with hepatic impairment.
গর্ভাবস্থায় ও স্তন্যদানকালে
Lymecycline are selectively absorbed by developing bones and teeth and may cause dental staining and enamel hypoplasia. In addition, these compounds readily cross the placental barrier and therefore Lymecycline should not be given to pregnant or lactating women.
সতর্কতা
Patient with myasthenia gravis. May exacerbate SLE. Hepatic impairment.
থেরাপিউটিক ক্লাস
Tetracycline group of drugs