Indications

This combination is indicated for the treatment of H. pylori infection in adults.

Composition

Pharmacology

Dosage & Administration

14 days daily administration for morning, mid-day and night dowing each containing the following two drug products: Tablet : Vonoprazan 20 mg Capsule : Amoxicillin 500 mg The recommended dosage regimen is Morning : 1 Vonoprazan 20 mg tablet & 2 Amoxicillin 500 mg capsules Midday : 2 Amoxicillin 500 mg capsules Night : 1 Vonoprazan 20 mg tablet & 2 Amoxicillin 500 mg capsules with or without food, for 14 days

Contraindications

Known hypersensitivity to Vonoprazan, Amoxicillin or any other beta-lactams, or any component of Vonomax Duo. Rilpivirine-containing products

Side Effects

Most common adverse reactions (22%) were diarrhea, abdominal pain, vulvovaginal candidiasis and nasopharyngitis.

Pregnancy & Lactation

Based on findings from animal studies and observational studies in pregnant women with use of Clarithromycin, use of Vonomax Duo is not recommended in pregnant women. Avoid breastfeeding during Voromax Duo therapy.

Precautions & Warnings

Hypersensitivity Reactions : Serious and occasionally fatal reactions (e.g., anaphylaxis) have been reported with components of Vonomax Duo. If hypersensitivity reactions occur, discontinue Vonomax Duo and institute immediate therapy (eg, anaphylaxis management). Severe Cutaneous Adverse Reactions (SCAR) : Discontinue Vonomax Duo at the first signs or symptoms of SCAR or other signs of Hypersensitivity and consider further evaluation. Clostridioides difficile-associated diarrhea (CDAD) : Evaluate if diarrhea occurs with Vonomax Duo.

Therapeutic Class

Storage Conditions

Store at below 30°C in a dry place protected from light. Keep out of reach of children.