Indications

The active ingredients of Vitamin C and Vitamin E have been linked with reduced risks of cardiovascular diseases in human. Concurrent intake of Vitamin E and Vitamin C suggests that their action may be synergistic.

Composition

Pharmacology

Vitamin C : Necessary for collagen formation and tissue repair; plays a role in oxidation/reduction reactions as well as other metabolic pathways including synthesis of catecholamines, carnitine, and steroids; also plays a role in conversion of folic acid to folinic acid. Vitamin E plays a role in protecting red blood cells against hemolysis; has protective effects against free radicals on polyunsaturated fatty acids found in cell membranes; plays a role in preventing oxidation of vitamin A and C.

Dosage & Administration

Vitamin C & E capsule is administered orally. The adult dose is 1 capsule daily or as directed by the registered physician.

Contraindications

Vitamin C in megadoses has been contra-indicated for patients with hyperoxaluria. A pregnant woman taking more than 5 gm daily ascorbate may suffer from fetal abortion. Higher doses of Vitamin C have reported to cause failure of conception. In case of Vitamin E, there is no absolute contra-indication.

Side Effects

Vitamin C is usually well tolerated. Large doses are reported to cause diarrhea and other gastrointestinal disturbances. Vitamin E is usually well tolerated. Large doses may cause diarrhea, abdominal discomfort, and other gastrointestinal disturbances, and have also been reported to cause fatigue and weakness.

Pregnancy & Lactation

Pregnancy Category A. Adequate and well-controlled human studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).

Precautions & Warnings

Vitamin C should be given with care to patient with hyperoxaluria. In patients taking oral anticoagulants or oestrogens Vitamin E should be given carefully because it has been found to antagonize the effects of Vitamin K leading to an increase in blood clotting time in these patients.

Therapeutic Class

Anti-oxidant Multivitamin preparations, Specific combined vitamin preparations

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.