নির্দেশনা

Jogaraj Guggulu is indicated in- Rheumatoid arthritis Osteoarthritis Neuralgias Myalgias Spondylitis Backaches Joint pain/ Arthralgia Joint stiffness

উপাদান

ফার্মাকোলজি

Jogaraj-guggulu is a right preparation of different herbs, which is therapeutically effective in rheumatoid disorder.The phytochemical constituents present in the herbs used for the preparation of Jogaraj-guggulu possibly facilitate the desirable therapeutic efficacy as a whole in ailments. Literature survey reveals that guggulsterone E & Z from Commiphora mukul, piperine from Piper longum are responsible for anti-inflammatory activity whereas gallic acid from Terminalia chebula & Terminalia belerica & ascorbic acid from Emblica officinalis are responsible for its antioxidant activity. Commiphora mukul : Guggulu is an exudates obtained in the form of oleogum resin from the stem of Commiphora mukul. It has analgesic & anti-inflammatory properties due to the presence of guggulsterone E & Z. Guggulsterone shows anti-inflammatory effect by inhibiting the activation of nuclear factor-kappa-B (NF-kappa-B). Plumbago zeylanicum : Plumbago zeylanicum possesses flavonoids, which are known to inhibit the prostaglandins synthesis. Flavonoids of Plumbago zeylanicum help to reduce pain perception by suppressing pain substances like prostaglandins & bradykinin. It also controls excessive collagenase production. Study reveals that analgesic effect is comparable to that of Indomethacin. Nigela sativa : Nigella sativa contains thymoquinone, which inhibits the effect of nociceptive system or inflammatory mediators and reduces pain. The anti-nociceptive effect of Nigella sativa is comparable with that of Naproxen. Vanda Roxburghii : Vanda Roxburghii reduces pain & inflammation. Heptacosane & octacosan of Vanda roxburghii shows anti-inflammatory activity. Zingiber officinale : Gingerol from Zingiber officinale possesses anti-inflammmatory and analgesic properties. This formulation inhibits production of prostaglandins & leukotrienes that are responsible for pain & inflammation. The rock salt used in the short term performance of these plants helps. This herb acts as a carrier material.

মাত্রা ও সেবনবিধি

One capsule 2-3 times a day after meals or as advised by the physician.

প্রতিনির্দেশনা

Jogaraj guggulu is contraindicated in cases of known allergy to plants or guggulu. It is well tolerated but precaution should be taken in hyperthyroidism, diarrhea, during use of antihypertensive, anti-fungal & lipid lowering medication.

পার্শ্ব প্রতিক্রিয়া

No severe side effects have been observed with Jogaraj guggulu during the clinical practice for the last twenty-five years; however, systematic Phase 1 study with this drug is carried out and general tolerability of Jogaraj guggulu is found good.Maximum tolerable dose is about 9 gm per day. In rare case very high dose than prescribed may lead to stomach irritation,diarrhea,stomatitis & urticaria.

গর্ভাবস্থায় ও স্তন্যদানকালে

Jogaraj guggulu should not be used during pregnancy or lactation.

সতর্কতা

থেরাপিউটিক ক্লাস

Herbal and Nutraceuticals

সংরক্ষণ

Keep in a cool,dry place & away from direct sun light.Keep the medicine out of children's reach.