Indications
This combination capsule is indicated in: Support for cardiovascular health Contribute to normal absorption and utilization of calcium and phosphorous in the body Contribute to normal blood clotting Contribute to the maintenance of normal bones
Composition
- Vitamin Ds (4000 IU) &
- Vitamin K2 (100 mcg).
Pharmacology
Vitamin K2 is necessary for the activation of osteocalcin, a protein that transports and integrates calcium into bone to ensure a healthy skeleton. Incorporating calcium into the bone matrix means that less calcium is available for harmful deposits in soft body tissues. Vitamin D3 (Cholecalciferol) is essential for normal bone growth & development and to maintain bone density. It also helps our body to utilize both Calcium & Phosphorus. The active form of Vitamin D3, Calcitriol, exerts its effect by binding to the Vitamin D receptors (VDRs) which are widely distributed through many body tissues.Vitamin D3 has a half life of about 50 days as it is fat soluble.Vitamin D3 is absorbed in the small intestine and bound to specific a-globulins and transported to the liver where it is metabolised to 25-hydroxy Vitamin D3 (Calcidiol). A second hydroxylation to 1,25-dihydroxy Vitamin D3 (Calcitriol) occurs in the kidney. This metabolite is responsible for the vitamin's ability to increase the absorption of calcium. Non-metabolised Vitamin D3 is stored in tissues such as fat and muscle.Vitamin D3 is eliminated via faeces and urine.
Dosage & Administration
Adults and children over 12 years of age: 1-2 capsule daily or as directed by the physician.
Contraindications
Contraindicated in patients with known hypersensitivity to any of the ingredients.
Side Effects
Well tolerated in recommended dose.
Pregnancy & Lactation
Vitamin K & D3 is safe in pregnancy & lactation when used as recommended doses.
Precautions & Warnings
Therapeutic Class
Herbal and Nutraceuticals
Storage Conditions
Store at a cool & dry place below 30°C temperature, Protect from direct sunlight & moisture. Do not freeze.