Indications

Parenteral amino acid supply in severe forms of hepatic failure (liver insufficiency) with and without encephalopathy. For supply of amino acids as part of a parenteral nutrition regimen when oral or enteral nutrition is impossible or insufficient or contraindicated.

Composition

• L-Isoleucine: 10.40 gm
• L-Leucine: 13.09 gm
• L-Lysine monoacetate: 9.71 gm
• L-Lysine 6.88 gm
• L-Methionine 1.1 gm
• Acetylcysteine 0.70 gm
• L-Cysteine 0.52 gm
• L-Phenylalanine 0.88 gm
• L-Threonine 4.40 gm
• L-Tryptophan 0.70 gm
• L-Valine 10.08 gm
• Arginine 10.72 gm
• L-Histidine 2.80 gm
• Aminoacetic acid 5.82 gm
• L-Alanine 4.64 gm
• L-Proline 5.73 gm
• L-Serine 2.24 gm
• Glacial acetic acid 4.42 gm
• Water for Injections q.s.

Pharmacology

Dosage & Administration

For intravenous infusion. Usual dose: 1.0 to 1.25 ml/kg/hour. Max. dosage: 1.5 g amino acids/kg/day = 1300 ml/day at 70 kg body weight. Constant checking of serum electrolytes, fluid balance and acid-base balance is mandatory. Amino Acid 8% is used as long as required by therapy.

Contraindications

Disturbance of amino acid metabolism, metabolic acidosis, fluid overload, hyponatremia, hypokalemia, renal insufficiency, decompensated cardiac insufficiency, shock, hypoxia. No specific studies have been performed to assess the safety of Amino Acid 8% in pregnancy and lactation.

Side Effects

Due to the special composition of this preparation, use in indications other than those recommended may result in amino acid imbalances and severe metabolic disorders.

Pregnancy & Lactation

Precautions & Warnings

Therapeutic Class

Parenteral nutritional preparations

Storage Conditions

Amino Acid 8% should not be stored after the addition of other components. Do not store above 25°C. Do not freeze. Shelf Life: 36 months. Do not use Amino Acid after the expiry date. Do not use if the solution is cloudy or if the container is damaged. Keep out of the reach of children.