নির্দেশনা
Mizolastine tablet is indicated for the symptomatic relief of the following conditions: Seasonal allergic rhinoconjunctivitis (hay fever) Perennial allergic rhinoconjunctivitis Urticaria
Composition
ফার্মাকোলজি
Mizolastine, a non-sedating antihistamine, blocks histamine H1-receptors on effector cells of the GI tract, blood vessels and respiratory tract. It also has mast-cell stabilising properties.
মাত্রা ও সেবনবিধি
Adult and children above 12 years : The usual recommended dose is one 10 mg tablet daily. Children below 12 years : Not recommended.
প্রতিনির্দেশনা
Mizolastine is contra-indicated in patients with clinically significant cardiac disease or a history of symptomatic arrhythmias and in patients with known or suspected QT prolongation, patients with electrolyte imbalance (particularly hypokalaemia), and in those with clinically significant bradycardia. It is also contra-indicated in patients taking other drugs that decrease its metabolism, patients with significantly impaired liver function, and in patients who are hypersensitive to the drug.
পার্শ্ব প্রতিক্রিয়া
Mizolastine is well tolerated in the recommended doses. The usual side effects are dry mouth, diarrhoea, abdominal pain, nausea, drowsiness, headache, dizziness, raised liver enzymes, hypotension, tachycardia and palpitations. Bronchospasm and aggravation of asthma were reported, but in view of the high frequency of asthma in the treated patient population, a causality relationship remains uncertain.
গর্ভাবস্থায় ও স্তন্যদানকালে
The safety of Mizolastine for use in human pregnancy has not been established. The evaluation of experimental animal studies does not indicate direct or indirect harmful effects with respect to the development of the embryo or foetus, the course of gestation and peri and post-natal development. Mizolastine should be avoided in pregnancy (particularly the 1 st trimester). Mizolastine is excreted into breast milk, therefore it is not recommended during lactation.
সতর্কতা
Patients should be warned that a small number of individuals may experience sedation. It is therefore advisable to determine individual response before driving or performing complicated task.
থেরাপিউটিক ক্লাস
Non-sedating antihistamines