নির্দেশনা

Eluxadoline is indicated in adults for the treatment of irritable bowel syndrome with diarrhea (IBS-D).

Composition

ফার্মাকোলজি

Eluxadoline is a mu-opioid receptor agonist, kappa opioid receptor agonist & delta opioid receptor antagonist. Eluxadoline works directly in intestine to reduce peristalsis, also makes the nerves in intestine less sensitive to stimulation.

মাত্রা ও সেবনবিধি

The recommended dose is 75 mg tablet taken orally twice daily with food. Patients who develop severe constipation for more than 4 days have to discontinue the drug. If a dose is missed, patient should take the next dose at the regular time and avoid taking two doses at a time. Pediatric Use : Safety and effectiveness in pediatric patients have not been established. Hepatic Impairment : It is contraindicated in patients with severe hepatic impairment.

প্রতিনির্দেশনা

Known or suspected biliary duct obstruction, sphincter of oddi disease or dysfunction & pancreatitis.

পার্শ্ব প্রতিক্রিয়া

Most common adverse reactions are constipation, nausea and abdominal pain.

গর্ভাবস্থায় ও স্তন্যদানকালে

Pregnancy: Not established. Lactation: Not established.

সতর্কতা

Sphincter of Oddi spasm and Pancreatitis. Patients who should be monitored closely- without a gallbladder with new or worsening abdominal pain with nausea and vomiting with acute biliary pain with liver or pancreatic enzyme elevation

থেরাপিউটিক ক্লাস

Carboxylic acids and derivatives, Prokinetic drugs

সংরক্ষণ